Program

Tuesday, September 10

12:45-13:00

Opening Address

Prof. Yasuhisa Asano, General Chair
Dr. Ingo Höllein, Embassy of the Federal Republic of Germany in Tokyo
Ms. Kyoko Suzuki, Embassy of Switzerland in Tokyo

13:00-13:15

Plenary Lecture

PL1

Forty-years of Japanese-German Workshop for Enzyme Technology and Japanese-Swiss Workshop for Bioprocess Development:My Personal Memory

Sakayu Shimizu
Professor Emeritus, Kyoto University, Japan

13:15-13:45

Keynote Lecture 1

KL1

Development of novel biotechnology tools stemmed from screening of microbial metabolisms supported by omics technologies

Jun Ogawa
Kyoto University, Japan

13:45-15:15

Oral Session 1
Bioprocess Development for Fine Chemical and Biofuel Production 1

O1-1

Photobiocatalysis and bioprocess development

Andreas Schmid
Helmholtz Center UFZ & MIKAT Center for Biocatalysis, Germany

O1-2

Syngas as a carbon source for polyhydroxyalkanoate biosynthesis during fed-batch cultivation of Rhodosprillum rubrum

Manfred Zinn
University of Applied Sciences and Arts Western Switzerland (HES-SO Valais), Switzerland

O1-3

Development of high-performance polybenzimidazole bioplastics from ktraft pulp

Yasuo Ohnishi
The University of Tokyo, Japan

O1-4

Applications of a photodecarboxylase for drop-in biofuel production

Johannes Kabisch
TU Darmstadt, Germany

O1-5

Biotransformation from L-phenylalanine to benzaldehyde by microbial enzymes

Hiroyuki Nozaki
Ajinomoto Co., Inc., Japan

O1-6

Using in situ-product crystallization (ISPC) to shift the reaction equilibria of selected transaminase-catalyzed reactions

Jan von Langermann
University of Rostock, Germany

Coffee Break

15:45-17:45

Oral Session 2
Enzyme Technology

O2-1

Unravelling the nature of electron transfer pathways in multi-component oxygenases and light-driven biocatalytic reactions

Sandy Schmidt
Graz University of Technology, Austria

O2-2

Effects of the introduction of pncB or pntAB on the 1-propanol fermentative production by the recombinant Escherichia coli

Michihiko Kataoka
Osaka Prefecture University, Japan

O2-3

Catalytically active inclusion bodies – tailoring properties and optimizing production

Jochen Buechs
AVT-Biochemical Engineering, RWTH Aachen University, Germany

O2-4

Boosting photobioredox catalysis by morpholine electron donors under aerobic conditions

Florian Rudroff
TU Wien, Austria

O2-5

S-adenosylhomocysteine as a methyl transfer catalyst in biocatalytic methylation reactions

Florian Seebeck
University of Basel, Switzerland

O2-6

Cysteine production through an in vitro biocatalytic cascade consisting of thermophilic enzymes

Kohsuke Honda
Osaka University, Japan

O2-7

Photobiocatalytic whole-cell biotransformations in cyanobacteria

Robert Kourist
Graz University of Technology, Austria

Wednesday, September 11

9:00-9:30

Keynote Lecture 2

KL2

Cyanide-free organic synthesis of nitriles by means of biocatalysis

Harald Gröger
Bielefeld University, Germany

9:30-10:40

Oral Session 3
Bioprocess Development for Fine Chemical and Biofuel Production 2

O3-1

Bioprocess Intensification Motivated Technological Developments

Andreas Liese
TUHH Hamburg University of Technology, Germay

O3-2

Regulation of phosphoenolpyruvate carboxylase (PEPC) by reversible acetylation in Corynebacterium glutamicum: its impact on L-glutamate overproduction

Saori Kosono
The University of Tokyo, Japan

O3-3

Enzyme catalysis and bioelectric systems: toward the integration of ionic liquid supported biotransformation with wet microalgae

Fabian Fischer
University of Applied Sciences and Arts of Western Switzerland, Switzerland

O3-4

Lonza's 40 years passion in Biotransformation and Custom Manufacturing

Yufeng Miao
Lonza Japan Ltd, Japan

Coffee Break

11:15-12:30

Oral Session 4
Protein Engineering and In-silico Design

O4-1

Design and evolution of artificial metalloenzymes

Donald Hilvert
ETH Zurich, Switzerland

O4-2

Engineering artificial metalloenzymes based on de novo metal-protein complexes

Cathleen Zeymer
ETH Zurich, Switzerland

O4-3

Protein engineering of FAD-GDH: Circular permutation combined with disulfide bond formation

Satoru Ishihara
Amano Enzyme Inc., Japan

O4-4

In silica protein engineering: tuning the properties of enzymes through supramolecular engineering

Patrick Shahgaldian
University of Applied Sciences and Arts Northwestern Switzerland, Switzerland

Lunch

13:30-15:15

Oral Session 5
Screening for enzymes and directed evolution

O5-1

Substrate specificity of tuliposide-converting enzyme, a unique non-ester-hydrolyzing carboxylesterase in tulip: effects of the alcohol moiety of substrate on the enzyme activity

Yasuo Kato
Toyama Prefectural University, Japan

O5-2

Biocatalytic oxidation processes with α-ketoglutarate dependent enzymes for sustainable chemical synthesis

Raphael Frey
ZHAW, Switzerland

O5-3

GNAT superfamily enzyme plays a key role in the biosynthesis of polyketide/peptide hybrid lipopeptides

Hiroyasu Onaka
The University of Tokyo, Japan

O5-4

Enzymatic Degradation of Algal Polysaccharides using CAZymes from Marine Bacteria

Uwe Bornscheuer
Greifswald University, Germany

O5-5

Elucidation of the entire CoA biosynthesis pathway in Archaea

Haruyuki Atomi
Kyoto University, Japan

O5-6

Genetically-encoded screening platform for development of oxidizing enzymes

Tsvetan Kardashliev
ETH Zurich, Switzerland

O5-7

Discovery of a novel suicide enzyme catalyzing multiple reactions in a single active site for biotin biosynthesis of cyanobacteria

Makoto Nishiyama
The University of Tokyo, Japan

Coffee Break

15:30-16:30

Poster Session

16:30-18:30

Toyama Pharmaceutical Valley Development Consortium Special Session

Introduction

Yasuhisa Asano
Toyama Prefectural University, Japan

PC1

Designing biocatalysts for biopharmaceuticals & healthcare products

Magali Remaud-Simeon
Toulouse Biotechnology Institute / INSA, France

PC2

Health promoting functional fatty acids generated by intestinal bacteria

Shigenobu Kishino
Kyoto University, Japan

PC3

Construction of plasmid-free bacterial strains for the synthesis of human milk oligosaccharides

Georg A. Sprenger
University of Stuttgart, Germany

PC4

Harnessing nature – biocatalysis for development and drug discovery

Rebecca Buller
Zurich University of Applied Sciences, Switzerland

PC5

Protein engineering of actinomycete CYP105A1 to produce active forms of vitamin D

Toshiyuki Sakaki
Toyama Prefectural University, Japan

Thursday, September 12

9:00-9:30

Keynote Lecture 3

KL3

Industrial biotechnology in the production and discovery of flavor and fragrance terpenes

Ernesto Simon
Firmenich SA, Switzerland

9:30-10:00

Special Session

SS1

Metabolic Enzymes for Streamlined Synthesis of Chiral Metabolites

Roland Wohlgemuth
Institute of Technical Biochemistry, Technical University Lodz, Poland

10:00-10:45

Oral Session 6
Synthesis Pharmaceutical Intermediates

O6-1

A novel enzyme module system for the one-pot synthesis of hyaluronic acid from sucrose and N-acetylglucosamine

Lothar Elling
RWTH Aachen University, Germany

O6-2

Synthetic enzyme cascades – from scratch to application

Dörte Rother
Forschungszentrum Jülich GmbH and RWTH Aachen University, Germany

O6-3

Key Building Blocks for Natural Product Synthesis via Enzyme-Mediated Transformations

Jörg Pietruszka
Institut für Bioorganische Chemie der Heinrich-Heine-Universität Düsseldorf, Germany

Coffee Break

11:15-12:00

Oral Session 7
Bioprocess Development for Fine Chemical and Biofuel Production 3

O7-1

Efficiency consideration in applied biocatalysis

Kai Baldenius, Germany

O7-2

CoA transferase from Thermus thermophilus is regulated by catalytically inactive alanine dehydrogenase-like protein

Ayako Yoshida
The University of Tokyo, Japan

O7-3

Ionic Liquid-Water-Based Thermomorphic Solvent Systems for Enzymatic Synthesis of Fine Chemicals

Udo Kragl
University of Rostock, Germany

12:00-12:15

Closing Ceremony

Poster Session

P01

An easy system for enzyme display on Bacillus subtilis spore surfaces

Marianna Karava
Computer-aided synthetic biology, Department of Biology, Technische Universität, Germany

P02

ERp29 assists dimerization of ER-resident molecular chaperone.

Hitomi Nakao
Department of Applied Chemistry, University of Toyama, Japan

P03

Characterization of uracil-thymine dehydrogenase in pyrimidine oxidative metabolism of Rhodococcus erythropolis JCM 3132

Michiki Takeuchi
Industrial Microbiology, Graduate School of Agriculture, Kyoto University, Japan

P04

Enzymatic process for useful amino acid synthesis using microbial Fe(II)/α-ketoglutarate-dependent dioxygenases

Ryotaro Hara
Industrial Microbiology, Graduate School of Agriculture, Kyoto University, Japan and Research Institute for Science and Engineering, Waseda University, Japan

P05

Isoprenoid production utilizing a hyperthermophilic archaeon

Takaaki Sato
Department of Synthetic Chemistry and Biological Chemistry, Graduate School of Engineering, Kyoto University, Japan

P06

Enzymatic synthesis of lacto-N-tetraose, a core structure of human milk oligosaccharide, using mutant phosphorylase

Takane Katayama
Kyoto University, Japan

P07

Crystal screening of aldoxime dehydratase from Bacillus sp. OxdB-1 for structural analysis

Daisuke Matsui
Toyama Prefectural University, Japan

P08

Hydroxynitrile lyases from two variants of passion fruits, Passiflora edulis Sims and Passiflora edulis forma flavicarpa: characterization and effect of C-terminal truncation on their stability

Aem Nuylert
Biotechnology Research Center and Department of Biotechnology, Toyama Prefectural University, Japan

P09

Aggregation hotspot in the β-sheet structure for the heterologous soluble expression

Suguru Shinoda
Toyama Prefectural University, Japan

P10

Chemo-enzymatic cascade synthesis of optically pure alkanoic acids using engineered arylmalonate decarboxylase variants

Junichi Enoki
Junior Research Group for Microbial Biotechnology, Ruhr-University Bochum, Germany

P11

Strategies to increase the potential use of oleaginous microalgae for biofuel production and phytoremediation: Nutrient starvations and co-cultivation with filamentous fungal pellets

Sirasit Srinuanpan
Toyama Prefectural University, Japan

P12

Tandem enzymatic reactions for the production of a phytochemical L-(+)-alliin

Makoto Hibi
Toyama Prefectural University, Japan

P13

Catalytic properties of the Fluoro Ketone Reductase (FKR) from Pichia farinosa NBRC0462

Sayaka Kamai
Toyama Prefectural University, Japan

P14

Purification and characterization of alcohol acyltransferases from Chamaemelum nobile and Durio zibethinus

Ryoutaro Oosima
Toyama Prefectural University, Japan